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PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM. An excellent preclinical in vitro ADME and safety profile.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 36.45 mL | 182.24 mL | 364.48 mL |
| 0.5 mM | 7.29 mL | 36.45 mL | 72.9 mL |
| 1 mM | 3.64 mL | 18.22 mL | 36.45 mL |
| 5 mM | 0.73 mL | 3.64 mL | 7.29 mL |
*The above data is based on the productmolecular weight 274.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18748 |
|---|---|
| Actions | Blocker |
| CAS No. | 1449473-97-5 |
| Formula | C15H22N4O |
| M. Wt | 274.36 |
| Purity | >98% |
| Synonyms | PF06305591, PF 06305591 |
| SMILES | CC(C)(C)C1=CC=C(NC([[email protected]]([[email protected]@H](C)C(N)=O)N)=N2)C2=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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