PF-06305591

Catalog No.: A18748

NaV1.8 blocker

PF-06305591

PF-06305591 Chemical Structure

CAS NO. 1449473-97-5

PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM. An excellent preclinical in vitro ADME and safety profile.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $160.00

Special Price $128.00

10 mg

Regular Price: $280.00

Special Price $224.00

50 mg

Regular Price: $980.00

Special Price $784.00

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Biological Activity

PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM. An excellent preclinical in vitro ADME and safety profile.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 36.45 mL 182.24 mL 364.48 mL
0.5 mM 7.29 mL 36.45 mL 72.9 mL
1 mM 3.64 mL 18.22 mL 36.45 mL
5 mM 0.73 mL 3.64 mL 7.29 mL

*The above data is based on the productmolecular weight 274.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18748
Actions Blocker
CAS No. 1449473-97-5
Formula C15H22N4O
M. Wt 274.36
Purity >98%
Synonyms PF06305591, PF 06305591
SMILES CC(C)(C)C1=CC=C(NC([[email protected]]([[email protected]@H](C)C(N)=O)N)=N2)C2=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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