PF-06445974 is a potent phosphodiesterase 4B (PDE4B) inhibitor with an IC50 of less than 1 nM, demonstrating high specificity compared to PDE4 isoforms A, C, and D, with IC50 values of 36 nM, 17 nM, and 4.7 nM, respectively. This radioligand is designed for positron emission tomography (PET) imaging, exhibiting excellent brain permeability and significant specific binding capabilities. PF-06445974 is a valuable tool for researching PDE4B-related neurobiological processes and diseases.
PF-06445974 is a potent phosphodiesterase 4B (PDE4B) inhibitor with an IC50 of less than 1 nM, demonstrating high specificity compared to PDE4 isoforms A, C, and D, with IC50 values of 36 nM, 17 nM, and 4.7 nM, respectively. This radioligand is designed for positron emission tomography (PET) imaging, exhibiting excellent brain permeability and significant specific binding capabilities. PF-06445974 is a valuable tool for researching PDE4B-related neurobiological processes and diseases.
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