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PF-06685249

Catalog No.: A57642
AMPK Activator
PF-06685249 is a potent allosteric activator of AMP-activated protein kinase (AMPK), exhibiting an EC50 of 12 nM for recombinant AMPK α1β1γ1. This compound has demonstrated efficacy in enhancing renal function in ZSF-1 rats with diabetic nephropathy. PF-06685249 is suitable for research applications targeting metabolic diseases and diabetic nephropathy.
PF-06685249 1467059-70-6 AMPK Activator
Grouped product items
Size Price Stock Qty
1mg
$35.00
In stock
5mg
$80.00
In stock
10mg
$135.00
In stock
25mg
$220.00
In stock
50mg
$315.00
In stock
100mg
$430.00
In stock
200mg
$575.00
In stock
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Research use only. We do not sell to patients.
Data Sheet SDS

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPF-06685249 is a potent allosteric activator of AMP-activated protein kinase (AMPK), exhibiting an EC50 of 12 nM for recombinant AMPK α1β1γ1. This compound has demonstrated efficacy in enhancing renal function in ZSF-1 rats with diabetic nephropathy. PF-06685249 is suitable for research applications targeting metabolic diseases and diabetic nephropathy.
Product Information
Catalog NumA57642
FormulaC17H16ClN3O3
Molecular Weight345.78
CAS Number1467059-70-6
SMILESO=C(C1=CNC2=C1C=C(C3=CC=C(N(C)C)N=C3OC)C(Cl)=C2)O
SynonymsPF-249
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PI3K/Akt/mTOR > AMPK