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PF-3758309 is a small-molecule p21-activated kinase inhibitor inhibiting oncogenic signaling and tumor growth.
Targets
| Target | Value |
|---|---|
| PAK4 | IC50: 1.3nM |
| PAK1 | ki: 13.7nM |
| PAK6 | ki: 17.1nM |
| PAK5 | ki: 18.1nM |
| PAK4 | ki: 18.7nM |
| PAK3 | IC50: 99nM |
| PAK2 | IC50: 190nM |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.4 mL | 102 mL | 204 mL |
| 0.5 mM | 4.08 mL | 20.4 mL | 40.8 mL |
| 1 mM | 2.04 mL | 10.2 mL | 20.4 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.08 mL |
*The above data is based on the productmolecular weight 490.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11930 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 490.2 |
| Formula | C25H30N8OS |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 898044-15-0 |
| Synonyms | PF-03758309 |
| SMILES | CC1=NC2=C(C(=N1)NC3=NNC4=C3CN(C4(C)C)C(=O)N[[email protected]](CN(C)C)C5=CC=CC=C5)SC=C2 |
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Contact information
United StatesAdooq Bioscience
Toll Free: (866) 930-6790
Fax: +1-323-606-8156
Email: [email protected]
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