PF-4989216

Catalog No.: A12889

PI3K inhibitor

PF-4989216

PF-4989216 Chemical Structure

CAS NO. 1276553-09-3

PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110??, p110??, p110??, p110??, and VPS34, respectively.

Availability: In stock

Package Price Qty
5 mg
$105.00
10 mg
$170.00
25 mg
$320.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110??, p110??, p110??, p110??, and VPS34, respectively.
Targets
p110δ p110α p110γ Vps34 p110β
1 nM2 nM65 nM110 nM142 nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.29 mL 131.44 mL 262.88 mL
0.5 mM 5.26 mL 26.29 mL 52.58 mL
1 mM 2.63 mL 13.14 mL 26.29 mL
5 mM 0.53 mL 2.63 mL 5.26 mL

*The above data is based on the productmolecular weight 380.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12889
Actions Inhibitor
M. Wt 380.4
Formula C18H13FN6OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1276553-09-3
Synonyms PF4989216, PF 4989216
SMILES C1COCCN1C2=C(C(=C(S2)C3=NC=NN3)C4=C(C=C(C=C4)C#N)F)C#N

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