PF-4989216

Name: PF-4989216
SKU: A12889

Catalog No.: A12889

PI3K inhibitor

PF-4989216

PF-4989216 Chemical Structure

CAS NO. 1276553-09-3

PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110??, p110??, p110??, p110??, and VPS34, respectively.

Availability: In stock

Package	Price	Qty
5 mg	$105.00
10 mg	$170.00
25 mg	$320.00

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Biological Activity

PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110??, p110??, p110??, p110??, and VPS34, respectively.

Targets

p110δ	p110α	p110γ	Vps34	p110β
1 nM	2 nM	65 nM	110 nM	142 nM

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.29 mL	131.44 mL	262.88 mL
0.5 mM	5.26 mL	26.29 mL	52.58 mL
1 mM	2.63 mL	13.14 mL	26.29 mL
5 mM	0.53 mL	2.63 mL	5.26 mL

*The above data is based on the productmolecular weight 380.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A12889
Actions	Inhibitor
M. Wt	380.4
Formula	C18H13FN6OS
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1276553-09-3
Synonyms	PF4989216, PF 4989216
SMILES	C1COCCN1C2=C(C(=C(S2)C3=NC=NN3)C4=C(C=C(C=C4)C#N)F)C#N