PF-5274857

Catalog No.: A12775

Smoothened Inhibitor

PF-5274857

PF-5274857 Chemical Structure

CAS NO. 1373615-35-0

PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ± 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ± 1.4 nmol/L in cells.

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5 mg

Regular Price: $81.00

Special Price $64.80

10 mg

Regular Price: $138.00

Special Price $110.40

25 mg

Regular Price: $243.00

Special Price $194.40

50 mg

Regular Price: $405.00

Special Price $324.00

10mM * 1mL in DMSO

Regular Price: $251.00

Special Price $200.80

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Biological Activity

PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ± 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ± 1.4 nmol/L in cells.
Targets
Smoothened Smoothened
4.6 nM(Ki)5.8 nM
In vitro (25°C) DMSO 83 mg/mL (189.95 mM)
Water 83 mg/mL (189.95 mM)
Ethanol Insoluble
In vivo Saline 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.89 mL 114.43 mL 228.85 mL
0.5 mM 4.58 mL 22.89 mL 45.77 mL
1 mM 2.29 mL 11.44 mL 22.89 mL
5 mM 0.46 mL 2.29 mL 4.58 mL

*The above data is based on the productmolecular weight 436.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12775
Actions Inhibitor
CAS No. 1373615-35-0
Formula C20H25ClN4O3S
M. Wt 436.96
Purity >98%
Synonyms PF5274857, PF 5274857
SMILES CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CCS(=O)(=O)C)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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