PF-5274857

Catalog No.: A12775

Smoothened Inhibitor

PF-5274857 Chemical Structure

CAS NO. 1373615-35-0

PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ± 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ± 1.4 nmol/L in cells.

Availability: In stock

Package Price Qty
5 mg
$160.00
10 mg
$225.00
25 mg
$460.00
50 mg
$930.00
10mM * 1mL in DMSO
$251.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ± 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ± 1.4 nmol/L in cells.
Targets
Smoothened Smoothened
4.6 nM(Ki)5.8 nM
In vitro (25°C) DMSO 93 mg/mL (212.83 mM)
Water 93 mg/mL (212.83 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.89 mL 114.43 mL 228.85 mL
0.5 mM 4.58 mL 22.89 mL 45.77 mL
1 mM 2.29 mL 11.44 mL 22.89 mL
5 mM 0.46 mL 2.29 mL 4.58 mL

*The above data is based on the productmolecular weight 436.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12775
Actions Inhibitor
M. Wt 436.96
Formula C20H25ClN4O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1373615-35-0
Synonyms PF5274857, PF 5274857
SMILES CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CCS(=O)(=O)C)C

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