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Biological Activity
PF-AKT400 is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50=0.5 nM) than PKA (IC50=450 nM).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.97 mL | 124.87 mL | 249.73 mL |
| 0.5 mM | 4.99 mL | 24.97 mL | 49.95 mL |
| 1 mM | 2.5 mL | 12.49 mL | 24.97 mL |
| 5 mM | 0.5 mL | 2.5 mL | 4.99 mL |
*The above data is based on the productmolecular weight 400.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A21991 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1004990-28-6 |
| Formula | C20H22F2N6O |
| M. Wt | 400.43 |
| Purity | >98% |
| Synonyms | AKT protein kinase inhibitor; PF-AKT400; PFAKT400; Lig1; Lig-1; Lig 1; PF AKT400; AKT-0286; AKT 0286; AKT0286 |
| SMILES | N[[email protected]@](CC1)(CNC(C2=CC=C(F)C=C2F)=O)CN1C3=C4C(NC=C4CC)=NC=N3 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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