Fig. 1 · Structure
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PFM046
Cat. No.
A74842
CAS
3053859-57-4
LXR Antagonist
PFM046 is a potent antagonist of the liver X receptors (LXRα and LXRβ), demonstrating IC50 values of 2.04 μM and 1.58 μM, respectively. This compound effectively inhibits the expression of stearoyl-CoA desaturase 1 (SCD1) and fatty acid synthase (FASN), while promoting the expression of ATP-binding cassette transporter A1 (ABCA1). PFM046 has shown promising antitumor efficacy in preclinical mouse models, making it a valuable tool for research in cancer therapeutics and lipid metabolism pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 3053859-57-4 |
| Applications | LXR Antagonist |
| Formula | C29H42O2 |
| Molecular Weight | 422.64 |
| SMILES | C[C@@]12[C@](CC[C@]2([H])[C@H](C)[C@H](CC3=CC=CC=C3)O)([H])[C@]4([H])CC=C5C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.