PG106 is a selective antagonist of the human melanocortin 3 (hMC3) receptor, exhibiting a potency with an IC50 of 210 nM. The compound demonstrates significant specificity, showing minimal activity at the hMC4 receptor (EC50 of 9900 nM) and no interaction with the hMC5 receptor. Research applications include studies focused on metabolic regulation and potential therapeutic targets related to obesity and related disorders.
PG106 is a selective antagonist of the human melanocortin 3 (hMC3) receptor, exhibiting a potency with an IC50 of 210 nM. The compound demonstrates significant specificity, showing minimal activity at the hMC4 receptor (EC50 of 9900 nM) and no interaction with the hMC5 receptor. Research applications include studies focused on metabolic regulation and potential therapeutic targets related to obesity and related disorders.
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