PGN36 is a selective antagonist of the cannabinoid CB2 receptor (CB2R), with a Ki of 0.09 µM for CB2R and >40 µM for CB1R. This compound effectively inhibits the upregulation of collagen type I gene expression induced by promoters of bone metabolism. Notably, PGN36 is capable of crossing the blood-brain barrier, making it a valuable tool for studying frontotemporal dementia (FTD) and other neurological conditions.
PGN36 is a selective antagonist of the cannabinoid CB2 receptor (CB2R), with a Ki of 0.09 µM for CB2R and >40 µM for CB1R. This compound effectively inhibits the upregulation of collagen type I gene expression induced by promoters of bone metabolism. Notably, PGN36 is capable of crossing the blood-brain barrier, making it a valuable tool for studying frontotemporal dementia (FTD) and other neurological conditions.
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