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Catalog No.: A11078

p38 MAPK inhibitor


PH-797804 Chemical Structure

CAS NO. 586379-66-0

PH-797804 is a diarylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase.

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5 mg
10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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  • Yuho Ito, .et al. MUC5B mucin production is upregulated by fibronectin and laminin in human lung epithelial cells via the integrin and ERK dependent pathway, Biosci Biotechnol Biochem, 2015, 79(11):1794-801 PMID: 26057585

Biological Activity

PH-797804 is a diarylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase.
p38α (Cell-free assay) p38β (Cell-free assay)
26 nM102 nM
In vitro (25°C) DMSO 84 mg/mL (175.99 mM)
Water Insoluble
Ethanol 6 mg/mL (12.57 mM)
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.96 mL 104.78 mL 209.56 mL
0.5 mM 4.19 mL 20.96 mL 41.91 mL
1 mM 2.1 mL 10.48 mL 20.96 mL
5 mM 0.42 mL 2.1 mL 4.19 mL

*The above data is based on the productmolecular weight 477.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11078
Actions Inhibitor
CAS No. 586379-66-0
Formula C22H19BrF2N2O3
M. Wt 477.2
Purity >98%
Synonyms PH797804

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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