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PH-797804

PH-797804

Name: PH-797804
Brand: Adooq Bioscience
SKU: A11078
Rating: 100 (1 reviews)

Catalog No.: A11078

p38 MAPK inhibitor

Product Citations (1)

PH-797804 Chemical Structure

CAS NO. 586379-66-0

PH-797804 is a diarylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase.

Availability: In stock

Package	Price	Qty
5 mg	$110.00
10 mg	$200.00
50 mg	$620.00
100 mg	$1,050.00
10mM * 1mL in DMSO	$164.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable papers

Publications Citing Use of Adooq PH-797804

Yuho Ito, .et al. MUC5B mucin production is upregulated by fibronectin and laminin in human lung epithelial cells via the integrin and ERK dependent pathway, Biosci Biotechnol Biochem, 2015, 79(11):1794-801 PMID: 26057585

Biological Activity

PH-797804 is a diarylpyridinone inhibitor of p38 mitogen-activated protein (MAP) kinase.

Targets

p38α (Cell-free assay)	p38β (Cell-free assay)
26 nM	102 nM

Solubility *

In vitro (25°C)	DMSO	84 mg/mL (175.99 mM)
	Water	Insoluble
	Ethanol	6 mg/mL (12.57 mM)
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.96 mL	104.78 mL	209.56 mL
0.5 mM	4.19 mL	20.96 mL	41.91 mL
1 mM	2.1 mL	10.48 mL	20.96 mL
5 mM	0.42 mL	2.1 mL	4.19 mL

*The above data is based on the productmolecular weight 477.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A11078
Actions	Inhibitor
CAS No.	586379-66-0
Formula	C22H19BrF2N2O3
M. Wt	477.2
Solubility	DMSO
Purity	>98%
Synonyms	PH797804
SMILES	CC1=C(C=C(C=C1)C(=O)NC)N2C(=CC(=C(C2=O)Br)OCC3=C(C=C(C=C3)F)F)C
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.