Phomopsinamine A is a potent tubulin inhibitor that effectively disrupts tubulin polymerization, exhibiting an IC50 of 0.53 μM. It inhibits the binding of Vinblastine to tubulin (IC50 = 0.56 μM) while enhancing the binding of Colchicine to tubulin (IC50 = 0.32 μM). This compound is valuable for studies investigating microtubule dynamics and their role in cellular processes, making it a useful tool in cancer research and the exploration of cytoskeletal modulation.
Phomopsinamine A is a potent tubulin inhibitor that effectively disrupts tubulin polymerization, exhibiting an IC50 of 0.53 μM. It inhibits the binding of Vinblastine to tubulin (IC50 = 0.56 μM) while enhancing the binding of Colchicine to tubulin (IC50 = 0.32 μM). This compound is valuable for studies investigating microtubule dynamics and their role in cellular processes, making it a useful tool in cancer research and the exploration of cytoskeletal modulation.
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