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$0.00 - Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844
Biological Activity
PI-3065 is a small molecule and selective inhibitor of p110δ kinase with an Ki value of 1.5nM and IC50 value of 5nM
Targets
| Target | Value |
|---|---|
| p110δ | IC50: 15nM |
| p110β | IC50: 1078nM |
| p110α | IC50: 2299nM |
| mTOR | IC50: 9082nM |
| DNA-PK | IC50: >10000nM |
| p110γ | IC50: 27542nM |
| In vitro | DMSO | Warmed: 50 mg/mL (98.68 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.74 mL | 98.69 mL | 197.38 mL |
| 0.5 mM | 3.95 mL | 19.74 mL | 39.48 mL |
| 1 mM | 1.97 mL | 9.87 mL | 19.74 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.95 mL |
*The above data is based on the productmolecular weight 506.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14338 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 955977-50-1 |
| Formula | C27H31FN6OS |
| M. Wt | 506.64 |
| Purity | >98% |
| Synonyms | PI3065, PI 3065 |
| SMILES | C1CC1CN2CCN(CC2)CC3=CC4=C(S3)C(=NC(=N4)C5=C(C=CC6=C5C=CN6)F)N7CCOCC7 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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