Catalog No.: A14338

p110δ inhibitor


PI-3065 Chemical Structure

CAS NO. 955977-50-1

PI-3065 is a small molecule and selective inhibitor of p110δ kinase with an Ki value of 1.5nM and IC50 value of 5nM

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  • Pridham KJ, .et al. PIK3CB/p110β is a selective survival factor for glioblastoma, Neuro Oncol, 2018, Mar 27;20(4):494-505 PMID: 29016844

Biological Activity

PI-3065 is a small molecule and selective inhibitor of p110δ kinase with an Ki value of 1.5nM and IC50 value of 5nM
Target Value
p110δIC50: 15nM
p110βIC50: 1078nM
p110αIC50: 2299nM
mTORIC50: 9082nM
DNA-PKIC50: >10000nM
p110γIC50: 27542nM
In vitro DMSO Warmed: 50 mg/mL (98.68 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.74 mL 98.69 mL 197.38 mL
0.5 mM 3.95 mL 19.74 mL 39.48 mL
1 mM 1.97 mL 9.87 mL 19.74 mL
5 mM 0.39 mL 1.97 mL 3.95 mL

*The above data is based on the productmolecular weight 506.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14338
Actions Inhibitor
CAS No. 955977-50-1
Formula C27H31FN6OS
M. Wt 506.64
Purity >98%
Synonyms PI3065, PI 3065

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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