Fig. 1 · Structure
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Picropodophyllin-d3
Stable Isotope
Picropodophyllin-d3 is a deuterium-labeled derivative of Picropodophyllin, specifically characterized as an insulin-like growth factor-1 receptor (IGF-1R) inhibitor, exhibiting an IC50 of 1 nM. This stable isotope is designed for use in metabolic studies and tracer experiments, providing enhanced sensitivity and precision in research applications. Its selective inhibition of IGF-1R makes it a valuable tool for investigating signaling pathways involved in cancer and metabolic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1454782-81-0 |
| Applications | Stable Isotope |
| Formula | C22H19D3O8 |
| Molecular Weight | 417.42 |
| Synonyms | AXL1717-d3; Picropodophyllotoxin-d3; PPP-d3 |
| SMILES | O=C1[C@@]2([H])[C@@](C3=CC(OC)=C(C(OC)=C3)OC([2H])([2H])[2H])([H])C4=CC(OCO5)=C5C=C4[C@@H]([C@@]2([H])CO1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.