Piperlongumine

Catalog No.: A14124

TrxR1/CRM1 inhibitor

Piperlongumine

Piperlongumine Chemical Structure

CAS NO. 20069-09-4

Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1).

Availability: In stock

Package Price Qty
25 mg
$90.00
50 mg
$150.00
10mM * 1mL in DMSO
$60.00
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Biological Activity

Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1).
Targets
reactive oxygen species (ROS)
In vitro (25°C) DMSO Warmed: 15 mg/mL (47.26 mM)
Water Insoluble
Ethanol Warmed: 6 mg/mL (18.9 mM)
In vivo 2% DMSO+40% PEG 300+2% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.52 mL 157.58 mL 315.16 mL
0.5 mM 6.3 mL 31.52 mL 63.03 mL
1 mM 3.15 mL 15.76 mL 31.52 mL
5 mM 0.63 mL 3.15 mL 6.3 mL

*The above data is based on the productmolecular weight 317.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14124
Actions Inducer
CAS No. 20069-09-4
Formula C17H19NO5
M. Wt 317.3
Purity >98%
Synonyms Piplartine
SMILES COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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