Piperlongumine

Catalog No.: A14124

TrxR1/CRM1 inhibitor

Piperlongumine Chemical Structure

CAS NO. 20069-09-4

Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1).

Availability: In stock

Package Price Qty
25 mg
$90.00
50 mg
$150.00
10mM * 1mL in DMSO
$60.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1).
Targets
reactive oxygen species (ROS)
In vitro DMSO 16 mg/mL heating (50.41 mM)
Water <1 mg/mL (<1 mM)
Ethanol 6 mg/mL heating (18.9 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.52 mL 157.58 mL 315.16 mL
0.5 mM 6.3 mL 31.52 mL 63.03 mL
1 mM 3.15 mL 15.76 mL 31.52 mL
5 mM 0.63 mL 3.15 mL 6.3 mL

*The above data is based on the productmolecular weight 317.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14124
Actions Inducer
M. Wt 317.3
Formula C17H19NO5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 20069-09-4
Synonyms Piplartine
SMILES COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O

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