PKC 412 (Midostaurin)

Catalog No.: A12650

PKC inhibitor

PKC 412 (Midostaurin) Chemical Structure

CAS NO. 120685-11-2

PKC 412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms α/β/γ, PDFRβ, VEGFR2, Syk, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.

Availability: In stock

Package Price Qty
5 mg
$90.00
10 mg
$145.00
25 mg
$260.00
50 mg
$405.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PKC 412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms α/β/γ, PDFRβ, VEGFR2, Syk, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.
Targets
Target Value
PKCαIC50: 22nM
PKCγIC50: 24nM
PKCβ1IC50: 30nM
PKCβ2IC50: 31nM
PPKIC50: 38nM
KDRIC50: 86nM
c-SykIC50: 95nM
PKCηIC50: 160nM
PKCδIC50: 330nM
Flk1IC50: 390nM
CDK1/CyclinBIC50: 570nM
PKAIC50: 570nM
c-FGRIC50: 790nM
c-SrcIC50: 800nM
FLT1IC50: 912nM
PLK1IC50: >1.0μM
p38IC50: >1μM
Tie-1IC50: >1μM
c-MetIC50: >1μM
EGFRIC50: 1.1μM
PKCεIC50: 1.25μM
Myosin-lightchainkinaseIC50: 1.9μM
c-LynIC50: 4.30μM
p70S6KIC50: 5.0μM
CSKIC50: 8.0μM
CDK4/CyclinD1IC50: >10μM
JunkinaseIC50: >10μM
Tie-2IC50: >10μM
FGFR1IC50: >10μM
v-AblIC50: >100μM
ERK1IC50: >200μM
CK1IC50: >200μM
CK2IC50: >200μM
PKBIC50: >300μM
PKCζIC50: 465μM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.52 mL 87.62 mL 175.24 mL
0.5 mM 3.5 mL 17.52 mL 35.05 mL
1 mM 1.75 mL 8.76 mL 17.52 mL
5 mM 0.35 mL 1.75 mL 3.5 mL

*The above data is based on the productmolecular weight 570.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12650
Actions Inhibitor
M. Wt 570.64
Formula C35H30N4O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 120685-11-2
Synonyms CGP 41251, PKC412, PKC-412, CGP41251, CGP-41251
SMILES C[[email protected]@]12[[email protected]@H]([[email protected]@H](C[[email protected]@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC

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