PNU-142586 sodium is a potent inhibitor of DNA topoisomerase 2-α (TOP2A) and DNA topoisomerase 2-β (TOP2B). This compound effectively disrupts DNA replication and transcription by preventing the binding of DNA to TOP2 and inhibiting ATP hydrolysis, resulting in antiproliferative and cytotoxic effects, including mitochondrial dysfunction. PNU-142586 sodium is primarily utilized in research investigating Linezolid-induced hematotoxicity and its underlying molecular mechanisms.
PNU-142586 sodium is a potent inhibitor of DNA topoisomerase 2-α (TOP2A) and DNA topoisomerase 2-β (TOP2B). This compound effectively disrupts DNA replication and transcription by preventing the binding of DNA to TOP2 and inhibiting ATP hydrolysis, resulting in antiproliferative and cytotoxic effects, including mitochondrial dysfunction. PNU-142586 sodium is primarily utilized in research investigating Linezolid-induced hematotoxicity and its underlying molecular mechanisms.
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