Polyquaternium-1 (Polidronium chloride; PQ-1) is an effective ophthalmic preservative with antimicrobial properties, which activates the NF-κB signaling pathway. It acts by targeting bacterial cell membranes, utilizing its polycationic nature to disrupt membrane integrity, inducing potassium ion leakage, and resulting in bacterial cell death. At a concentration of 0.001%, Polyquaternium-1 exhibits low toxicity towards mammalian cells, making it suitable for various formulations including glaucoma eye drops, artificial tears, and contact lens solutions. Its use helps to mitigate the ocular surface toxicity associated with conventional preservatives like benzalkonium chloride.
Polyquaternium-1 (Polidronium chloride; PQ-1) is an effective ophthalmic preservative with antimicrobial properties, which activates the NF-κB signaling pathway. It acts by targeting bacterial cell membranes, utilizing its polycationic nature to disrupt membrane integrity, inducing potassium ion leakage, and resulting in bacterial cell death. At a concentration of 0.001%, Polyquaternium-1 exhibits low toxicity towards mammalian cells, making it suitable for various formulations including glaucoma eye drops, artificial tears, and contact lens solutions. Its use helps to mitigate the ocular surface toxicity associated with conventional preservatives like benzalkonium chloride.
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