Pomalidomide-PEG1-C2-N3 is an E3 ligase ligand-linker conjugate that combines a Pomalidomide-based cereblon ligand with a one-unit PEG linker, facilitating the development of PROTACs. This compound is particularly effective in creating selective CDK6 degrader molecules, such as CP-10, which induces CDK6 degradation with a DC50 of 2.1 nM. Additionally, Pomalidomide-PEG1-C2-N3 features an azide functionality that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions, making it a versatile tool for click chemistry applications in chemical biology.
Pomalidomide-PEG1-C2-N3 is an E3 ligase ligand-linker conjugate that combines a Pomalidomide-based cereblon ligand with a one-unit PEG linker, facilitating the development of PROTACs. This compound is particularly effective in creating selective CDK6 degrader molecules, such as CP-10, which induces CDK6 degradation with a DC50 of 2.1 nM. Additionally, Pomalidomide-PEG1-C2-N3 features an azide functionality that enables it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions, making it a versatile tool for click chemistry applications in chemical biology.
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