Pomalidomide-PEG3-azide is an E3 ligase ligand-linker conjugate that combines the cereblon ligand derived from Pomalidomide with a three-unit polyethylene glycol (PEG) linker, essential for PROTAC (Proteolysis Targeting Chimeras) technology. This compound serves as a versatile click chemistry reagent, featuring an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. Its unique properties make it valuable for targeted protein degradation research and related applications in chemical biology.
Pomalidomide-PEG3-azide is an E3 ligase ligand-linker conjugate that combines the cereblon ligand derived from Pomalidomide with a three-unit polyethylene glycol (PEG) linker, essential for PROTAC (Proteolysis Targeting Chimeras) technology. This compound serves as a versatile click chemistry reagent, featuring an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it enables strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. Its unique properties make it valuable for targeted protein degradation research and related applications in chemical biology.
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