Pomalidomide-PEG4-azide is an E3 ligase ligand-linker conjugate that features the Pomalidomide-based cereblon ligand, combined with a PEG4 linker for use in PROTAC technology. This compound serves as a versatile click chemistry reagent, capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkynyl-containing molecules, as well as enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. It is primarily utilized in the development of targeted protein degradation strategies and other bioconjugation applications.
Pomalidomide-PEG4-azide is an E3 ligase ligand-linker conjugate that features the Pomalidomide-based cereblon ligand, combined with a PEG4 linker for use in PROTAC technology. This compound serves as a versatile click chemistry reagent, capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkynyl-containing molecules, as well as enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. It is primarily utilized in the development of targeted protein degradation strategies and other bioconjugation applications.
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