PP121

Catalog No.: A11207

PI3K Inhibitor

PP121

PP121 Chemical Structure

CAS NO. 1092788-83-4

PP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR).

Availability: In stock

Package Price Qty
10 mg

Regular Price: $80.00

Special Price $72.00

25 mg

Regular Price: $160.00

Special Price $144.00

50 mg

Regular Price: $280.00

Special Price $252.00

100 mg

Regular Price: $450.00

Special Price $405.00

10mM * 1mL in DMSO

Regular Price: $85.00

Special Price $76.50

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR).
Targets
Target Value
PDGFRIC50: 2nM
HckIC50: 8nM
VEGFRIC50: 12nM
mTORIC50: 13nM
SrcIC50: 14nM
AblIC50: 18nM
p110αIC50: 52nM
DNA-PKIC50: 60nM
p110δIC50: 150nM
EphB4IC50: 190nM
EGFRIC50: 260nM
p110γIC50: 1.1μM
p110βIC50: 1.4μM
In vitro DMSO 64 mg/mL (200.4 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (6.26 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.31 mL 156.56 mL 313.13 mL
0.5 mM 6.26 mL 31.31 mL 62.63 mL
1 mM 3.13 mL 15.66 mL 31.31 mL
5 mM 0.63 mL 3.13 mL 6.26 mL

*The above data is based on the productmolecular weight 319.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11207
Actions Inhibitor
M. Wt 319.36
Formula C17H17N7
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1092788-83-4
Synonyms PP-121
SMILES C1CCC(C1)N2C3=C(C(=N2)C4=CN=C5C(=C4)C=CN5)C(=NC=N3)N

Product Tags

Product Tags

Use spaces to separate tags. Use single quotes (') for phrases.

Product Questions

Product Questions

No Questions
Keywords:buy PP121 | PP121 Supplier | purchase PP121 | PP121 cost | PP121 manufacturer | order PP121 | PP121 distributor | buy 1092788-83-4| 1092788-83-4 Supplier | purchase 1092788-83-4 | 1092788-83-4 cost | 1092788-83-4 manufacturer | order 1092788-83-4 | 1092788-83-4 distributor
Rewards