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Biological Activity
PP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR).
Targets
| Target | Value |
|---|---|
| PDGFR | IC50: 2nM |
| Hck | IC50: 8nM |
| VEGFR | IC50: 12nM |
| mTOR | IC50: 13nM |
| Src | IC50: 14nM |
| Abl | IC50: 18nM |
| p110α | IC50: 52nM |
| DNA-PK | IC50: 60nM |
| p110δ | IC50: 150nM |
| EphB4 | IC50: 190nM |
| EGFR | IC50: 260nM |
| p110γ | IC50: 1.1μM |
| p110β | IC50: 1.4μM |
| In vitro | DMSO | 63 mg/mL (197.27 mM) | |
| Water | Insoluble | ||
| Ethanol | 2 mg/mL (6.26 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.31 mL | 156.56 mL | 313.13 mL |
| 0.5 mM | 6.26 mL | 31.31 mL | 62.63 mL |
| 1 mM | 3.13 mL | 15.66 mL | 31.31 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.26 mL |
*The above data is based on the productmolecular weight 319.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11207 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1092788-83-4 |
| Formula | C17H17N7 |
| M. Wt | 319.36 |
| Purity | >98% |
| Synonyms | PP-121 |
| SMILES | C1CCC(C1)N2C3=C(C(=N2)C4=CN=C5C(=C4)C=CN5)C(=NC=N3)N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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