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PI3K Inhibitor

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Catalog No. A11207

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PP121 10mg A11207-10

Regular Price: €76.00

Special Price: €68.40

PP121 25mg A11207-25

Regular Price: €152.00

Special Price: €136.80

PP121 50mg A11207-50

Regular Price: €266.00

Special Price: €239.40

PP121 100mg A11207-100

Regular Price: €427.50

Special Price: €384.75

PP121 10mM * 1mL in DMSO A11207-10mM-D

Regular Price: €80.75

Special Price: €72.68

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR).


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Chemical Information

Catalog Num A11207
Actions Inhibitor
M. Wt 319.36
Formula C17H17N7
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1092788-83-4
Synonyms PP-121

Biological Activity

PP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR).
Target Value
HckIC50: 8nM
mTORIC50: 13nM
SrcIC50: 14nM
AblIC50: 18nM
p110αIC50: 52nM
DNA-PKIC50: 60nM
p110δIC50: 150nM
EphB4IC50: 190nM
EGFRIC50: 260nM
p110γIC50: 1.1μM
p110βIC50: 1.4μM


Solubility (25°C)* In vitro DMSO 64 mg/mL (200.4 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (6.26 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.31 mL 156.56 mL 313.13mL
0.5 mM 6.26 mL 31.31 mL 62.63 mL
1 mM 3.13 mL 15.66 mL 31.31 mL
5 mM 0.63 mL 3.13 mL 6.26 mL

*The above data is based on the productmolecular weight 319.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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