PP242 (Torkinib)

Catalog No.: A10746

mTOR Inhibitor

PP242 (Torkinib)

PP242 (Torkinib) Chemical Structure

CAS NO. 1092351-67-1

PP242 is a potent and selective mTOR inhibitor in both mTORC1 and mTORC2.

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5 mg

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Special Price $40.00

10 mg

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Special Price $56.00

50 mg

Regular Price: $140.00

Special Price $112.00

100 mg

Regular Price: $240.00

Special Price $192.00

10mM * 1mL in DMSO

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Special Price $40.00

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  • Hiroshi Fukamachi, .et al. A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors, J Exp Clin Cancer Res, 2019, 38:127
  • Fuse MJ, .et al. Mechanisms of Resistance to NTRK Inhibitors and Therapeutic Strategies in NTRK1-Rearranged Cancers, Mol Cancer Ther, 2017, Oct;16(10):2130-2143 PMID: 28751539

Biological Activity

PP242 is a potent and selective mTOR inhibitor in both mTORC1 and mTORC2.
Targets
Target Value
mTORIC50: 8nM
p110δIC50: 0.10μM
DNA-PKIC50: 0.41μM
PDGFRIC50: 0.41μM
HckIC50: 1.2μM
p110γIC50: 1.3μM
SrcIC50: 1.4μM
VEGFR2IC50: 1.5μM
p110αIC50: 2.0μM
p110βIC50: 2.2μM
EphB4IC50: 3.4μM
AblIC50: 3.6μM
EGFRIC50: 4.4μM
Src(T338I)IC50: 5.1μM
In vitro (25°C) DMSO 57 mg/mL (184.86 mM)
Water Insoluble
Ethanol 17 mg/mL (55.13 mM)
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.44 mL 162.18 mL 324.36 mL
0.5 mM 6.49 mL 32.44 mL 64.87 mL
1 mM 3.24 mL 16.22 mL 32.44 mL
5 mM 0.65 mL 3.24 mL 6.49 mL

*The above data is based on the productmolecular weight 308.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10746
Actions Inhibitor
CAS No. 1092351-67-1
Formula C16H16N6O
M. Wt 308.3
Purity >98%
Synonyms PP-242
SMILES CC(C)N1C2=C(/C(=C\3/C=C4C=C(C=CC4=N3)O)/N1)C(=NC=N2)N
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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