PP242 (Torkinib)

Catalog No.: A10746

mTOR Inhibitor

PP242 (Torkinib) Chemical Structure

CAS NO. 1092351-67-1

PP242 is a potent and selective mTOR inhibitor in both mTORC1 and mTORC2.

Availability: In stock

Package Price Qty
5 mg
$50.00
10 mg
$70.00
50 mg
$140.00
100 mg
$240.00
10mM * 1mL in DMSO
$50.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PP242 is a potent and selective mTOR inhibitor in both mTORC1 and mTORC2.
Targets
Target Value
mTORIC50: 8nM
p110δIC50: 0.10μM
DNA-PKIC50: 0.41μM
PDGFRIC50: 0.41μM
HckIC50: 1.2μM
p110γIC50: 1.3μM
SrcIC50: 1.4μM
VEGFR2IC50: 1.5μM
p110αIC50: 2.0μM
p110βIC50: 2.2μM
EphB4IC50: 3.4μM
AblIC50: 3.6μM
EGFRIC50: 4.4μM
Src(T338I)IC50: 5.1μM
In vitro (25°C) DMSO 62 mg/mL (201.07 mM)
Water <1 mg/mL (<1 mM)
Ethanol 18 mg/mL (58.37 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.44 mL 162.18 mL 324.36 mL
0.5 mM 6.49 mL 32.44 mL 64.87 mL
1 mM 3.24 mL 16.22 mL 32.44 mL
5 mM 0.65 mL 3.24 mL 6.49 mL

*The above data is based on the productmolecular weight 308.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10746
Actions Inhibitor
M. Wt 308.3
Formula C16H16N6O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1092351-67-1
Synonyms PP-242
SMILES CC(C)N1C2=C(/C(=C\3/C=C4C=C(C=CC4=N3)O)/N1)C(=NC=N2)N

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