PPARδ Agonist 13 is a highly selective and potent agonist for the peroxisome proliferator-activated receptor delta (PPARδ), demonstrating an EC50 of 0.50 nM. By binding to the PPARδ ligand-binding pocket, it effectively upregulates the expression of PPARδ target genes. This compound inhibits renal fibroblast activation, restores fatty acid oxidation, and mitigates TGF-β1-induced renal fibroblast activation, showcasing its anti-fibrotic effects in a mouse model of unilateral ureteral obstruction. PPARδ Agonist 13 serves as a valuable tool for investigating the mechanisms of renal fibrosis.
PPARδ Agonist 13 is a highly selective and potent agonist for the peroxisome proliferator-activated receptor delta (PPARδ), demonstrating an EC50 of 0.50 nM. By binding to the PPARδ ligand-binding pocket, it effectively upregulates the expression of PPARδ target genes. This compound inhibits renal fibroblast activation, restores fatty acid oxidation, and mitigates TGF-β1-induced renal fibroblast activation, showcasing its anti-fibrotic effects in a mouse model of unilateral ureteral obstruction. PPARδ Agonist 13 serves as a valuable tool for investigating the mechanisms of renal fibrosis.
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