PPARδ Agonist 9 is a potent agonist of the peroxisome proliferator-activated receptor delta (PPARδ), exhibiting an EC50 of 3.6 nM. This compound demonstrates significant in vivo efficacy, evidenced by its ability to lower serum levels of MCP-1 in murine models. Additionally, PPARδ Agonist 9 effectively inhibits the progression of atherosclerosis in the LDL receptor knockout mouse model, achieving an inhibition rate of 50-60%. This makes it a valuable tool for research into metabolic disorders and cardiovascular diseases.
PPARδ Agonist 9 is a potent agonist of the peroxisome proliferator-activated receptor delta (PPARδ), exhibiting an EC50 of 3.6 nM. This compound demonstrates significant in vivo efficacy, evidenced by its ability to lower serum levels of MCP-1 in murine models. Additionally, PPARδ Agonist 9 effectively inhibits the progression of atherosclerosis in the LDL receptor knockout mouse model, achieving an inhibition rate of 50-60%. This makes it a valuable tool for research into metabolic disorders and cardiovascular diseases.
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