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PRL 3195

Catalog No.: A63874
Somatostatin Receptor Antagonist
PRL 3195 is a somatostatin receptor antagonist that exhibits inhibition constants (Kis) of 6, 17, 66, 1000, and 1000 nM for human somatostatin receptors sst5, sst2, sst3, sst1, and sst4, respectively. This compound is utilized in research to investigate the role of somatostatin signaling in various physiological and pathological processes. Its selective blockade of somatostatin receptors makes it a valuable tool for studying neuroendocrine regulation and potential therapeutic applications in disorders involving somatostatin dysregulation.
PRL 3195 341519-04-8 Somatostatin Receptor Antagonist
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPRL 3195 is a somatostatin receptor antagonist that exhibits inhibition constants (Kis) of 6, 17, 66, 1000, and 1000 nM for human somatostatin receptors sst5, sst2, sst3, sst1, and sst4, respectively. This compound is utilized in research to investigate the role of somatostatin signaling in various physiological and pathological processes. Its selective blockade of somatostatin receptors makes it a valuable tool for studying neuroendocrine regulation and potential therapeutic applications in disorders involving somatostatin dysregulation.
Product Information
Catalog NumA63874
FormulaC58H69ClN12O9S2
Molecular Weight1177.83
CAS Number341519-04-8
Sequence{Phe<4Cl>}-{d-Cys}-{β-Ala<3-Py>}-{d-Trp}-{Lys}-Thr-Cys-{2-Nal}-NH2 (Disulfide bridge:Cys2-Cys7)
Sequence shortening{F<4Cl>}-{d-C}-{β-A<3-Py>}-{d-W}-{K}-TC-{2-Nal}-NH2 (Disulfide bridge:Cys2-Cys7)
SMILES[H][C@]1(NC(=O)[C@H](CCCCN)N(C)C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2cccnc2)NC(=O)[C@@H](CSSC[C@H](NC1=O)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(N)=O)NC(=O)[C@@H](N)Cc1ccc(Cl)cc1)[C@@H](C)O
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GPCR/G Protein > Somatostatin Receptors