PRMT7-IN-2 is a selective inhibitor of Protein Arginine Methyltransferase 7 (PRMT7) with an IC50 value of 0.50 μM. This compound effectively arrests the cell cycle at the G0/G1 phase and promotes apoptosis, leading to inhibition of cell growth both in vivo and in vitro. PRMT7-IN-2 decreases monomethylarginine levels associated with PRMT7 activity and modulates epithelial and mesenchymal marker expression, enhancing the levels of E-cadherin while reducing those of N-cadherin, Vimentin, and ZEB2. Such properties make it a valuable tool for studying cancer biology and cellular transformation mechanisms.
PRMT7-IN-2 is a selective inhibitor of Protein Arginine Methyltransferase 7 (PRMT7) with an IC50 value of 0.50 μM. This compound effectively arrests the cell cycle at the G0/G1 phase and promotes apoptosis, leading to inhibition of cell growth both in vivo and in vitro. PRMT7-IN-2 decreases monomethylarginine levels associated with PRMT7 activity and modulates epithelial and mesenchymal marker expression, enhancing the levels of E-cadherin while reducing those of N-cadherin, Vimentin, and ZEB2. Such properties make it a valuable tool for studying cancer biology and cellular transformation mechanisms.
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