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Proinsulin C-peptide (human)

Catalog No.: A33747
Peptide Connecting The A And B Chains Of Proinsulin
Proinsulin C-peptide (human) is a 31-amino acid peptide that facilitates the proper folding of proinsulin by connecting its A and B chains. This peptide has been shown to inhibit high glucose-induced upregulation of PDGF-β receptor protein expression and the phosphorylation of p42/p44 MAP kinase. Additionally, Proinsulin C-peptide enhances the deformability of erythrocytes in type 1 diabetes and suppresses the proliferation of rat aortic smooth muscle cells under hyperglycemic conditions, with potential implications for vascular complications in diabetes research.
Proinsulin C-peptide (human) 33017-11-7 Peptide Connecting The A And B Chains Of Proinsulin
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Size Price Stock Qty
1mg
$280.00
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5mg
$720.00
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10mg
$1,175.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionProinsulin C-peptide (human) is a 31-amino acid peptide that facilitates the proper folding of proinsulin by connecting its A and B chains. This peptide has been shown to inhibit high glucose-induced upregulation of PDGF-β receptor protein expression and the phosphorylation of p42/p44 MAP kinase. Additionally, Proinsulin C-peptide enhances the deformability of erythrocytes in type 1 diabetes and suppresses the proliferation of rat aortic smooth muscle cells under hyperglycemic conditions, with potential implications for vascular complications in diabetes research.
Product Information
Catalog NumA33747
FormulaC129H211N35O48
Molecular Weight3020.26
CAS Number33017-11-7
SequenceGlu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly-Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln
Sequence shorteningEAEDLQVGQVELGGGPGAGSLQPLALEGSLQ
SMILESC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC(CNC(=O)[C@H]1N(C(CNC(CNC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)N)=O)C)=O)CCC(O)=O)=O)CC(O)=O)=O)CC(C)C)=O)CCC(N)=O)=O)C(C)C)=O)=O)CCC(N)=O)=O)[C@H](C)C)=O)CCC(O)=O)=O)CC(C)C)=O)=O)=O)=O)CCC1)=O)C)=O)=O)CO)=O)CC(C)C)=O)CCC(N)=O)(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(O)=O)=O)CC(C)C)=O)CO)=O)=O)CCC(O)=O)=O)CC(C)C)=O)C)=O)CC(C)C)=O)CCC2
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