Fig. 1 · Structure
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Propargyl-PEG2-OH
PROTAC Linkers
Propargyl-PEG2-OH is a PEG-based PROTAC linker that facilitates the synthesis of Thalidomide-O-PEG2-propargyl. This compound contains an alkyne functional group, enabling efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application in research allows for the development of targeted protein degradation strategies, making it a valuable tool for studies in therapeutic intervention and cellular regulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 7218-43-1 |
| Applications | PROTAC Linkers |
| Formula | C7H12O3 |
| Molecular Weight | 144.17 |
| SMILES | C#CCOCCOCCO |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.