Propargyl-PEG4-acid functions as a versatile PROTAC linker, facilitating the development of targeted protein degradation strategies. This PEG-based compound enables the synthesis of BTK-IAP PROTACs, including Ibrutinib-based analogues, significantly enhancing BTK degradation with a DC50 of 200 nM in THP-1 cells. Additionally, it possesses an alkyne group, making it a valuable clickable reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, thereby expanding its utility in chemical biology research.
Propargyl-PEG4-acid functions as a versatile PROTAC linker, facilitating the development of targeted protein degradation strategies. This PEG-based compound enables the synthesis of BTK-IAP PROTACs, including Ibrutinib-based analogues, significantly enhancing BTK degradation with a DC50 of 200 nM in THP-1 cells. Additionally, it possesses an alkyne group, making it a valuable clickable reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions, thereby expanding its utility in chemical biology research.
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