Propranolol-d7 (ring-d7) is a deuterated analogue of Propranolol hydrochloride, a nonselective β-adrenergic receptor antagonist. It exhibits high affinity for both β1 and β2 adrenergic receptors, with Ki values of 1.8 nM and 0.8 nM, respectively. This compound inhibits [3H]-DHA binding in rat brain membranes with an IC50 of 12 nM, making it a valuable tool for studying cardiovascular conditions such as hypertension, myocardial infarction, and cardiac arrhythmias. Propranolol-d7 (ring-d7) is particularly useful in pharmacokinetic and metabolic studies using mass spectrometry due to its stable isotope labeling.
Propranolol-d7 (ring-d7) is a deuterated analogue of Propranolol hydrochloride, a nonselective β-adrenergic receptor antagonist. It exhibits high affinity for both β1 and β2 adrenergic receptors, with Ki values of 1.8 nM and 0.8 nM, respectively. This compound inhibits [3H]-DHA binding in rat brain membranes with an IC50 of 12 nM, making it a valuable tool for studying cardiovascular conditions such as hypertension, myocardial infarction, and cardiac arrhythmias. Propranolol-d7 (ring-d7) is particularly useful in pharmacokinetic and metabolic studies using mass spectrometry due to its stable isotope labeling.
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