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PROTAC AR Degrader-11

Catalog No.: A84578
Androgen Receptor PROTAC Degrader
PROTAC AR Degrader-11 is a targeted degrader of the androgen receptor and androgen receptor splice variant-7, utilizing a proteolysis-targeting chimeric (PROTAC) approach. This compound exhibits significant cytotoxicity against prostate cancer cell lines, specifically CWR22RV1 and VCaP. PROTAC AR Degrader-11 is applicable in prostate cancer research, aiding investigations into androgen receptor modulation and degradation mechanisms.
PROTAC AR Degrader-11 2798907-41-0 Androgen Receptor PROTAC Degrader
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionPROTAC AR Degrader-11 is a targeted degrader of the androgen receptor and androgen receptor splice variant-7, utilizing a proteolysis-targeting chimeric (PROTAC) approach. This compound exhibits significant cytotoxicity against prostate cancer cell lines, specifically CWR22RV1 and VCaP. PROTAC AR Degrader-11 is applicable in prostate cancer research, aiding investigations into androgen receptor modulation and degradation mechanisms.
Product Information
Catalog NumA84578
FormulaC36H39F3N8O6
Molecular Weight736.74
CAS Number2798907-41-0
SMILESO=C(COCCCCOC1=CC=C(C2CCN(CC2)C3=NN4C(CC3)=NN=C4C(F)(F)F)C=C1)NC5=CC=CC6=C5CN(C7C(NC(CC7)=O)=O)C6=O
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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Endocrinology-Hormones > Androgen Receptors