PROTAC EGFR Degrader 13 is a targeted protein degradation compound that selectively degrades the epidermal growth factor receptor (EGFR). This degrader exhibits potent antiproliferative activity with an IC50 of 15.6 nM against Ba/F3 cells harboring the EGFR T790M-L858R-C797S mutations, demonstrating its effectiveness in EGFR-related cancer research. This reagent is suitable for investigating the underlying mechanisms of EGFR-driven malignancies and developing therapeutic strategies focused on targeted degradation pathways.
PROTAC EGFR Degrader 13 is a targeted protein degradation compound that selectively degrades the epidermal growth factor receptor (EGFR). This degrader exhibits potent antiproliferative activity with an IC50 of 15.6 nM against Ba/F3 cells harboring the EGFR T790M-L858R-C797S mutations, demonstrating its effectiveness in EGFR-related cancer research. This reagent is suitable for investigating the underlying mechanisms of EGFR-driven malignancies and developing therapeutic strategies focused on targeted degradation pathways.
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