PROTAC ER Degrader-3

Catalog No.: A18519

PROTAC ER Degrader-3

PROTAC ER Degrader-3 Chemical Structure

CAS NO. 2158322-29-1

PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab).

Availability: In stock

Package Price Qty
5 mg

Regular Price: $468.00

Special Price $374.40

10 mg

Regular Price: $806.00

Special Price $644.80

50 mg

Regular Price: $2,392.00

Special Price $1,913.60

100 mg

Regular Price: $4,784.00

Special Price $3,827.20

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Biological Activity

PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 8.19 mL 40.97 mL 81.94 mL
0.5 mM 1.64 mL 8.19 mL 16.39 mL
1 mM 0.82 mL 4.1 mL 8.19 mL
5 mM 0.16 mL 0.82 mL 1.64 mL

*The above data is based on the productmolecular weight 1220.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18519
Actions Degrader
CAS No. 2158322-29-1
Formula C71H77N7O12
M. Wt 1220.41
Purity >98%
SMILES OC1=CC=C(/C(C2=CC=C(OCCN(C)C(COCCOCCNC(C3=CC=C(C(N4[[email protected]@H](C)[[email protected]](NC([[email protected]](C)N(C(OC(C)(C)C)=O)C)=O)C(N(CC5=C(OC)C=CC6=C5C=CC=C6)C7=C4C=C(C#N)C=C7)=O)=O)C=C3)=O)=O)C=C2)=C(CC)/C8=CC=CC=C8)C=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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