PROTAC ER Degrader-3

Catalog No.: A18519

PROTAC ER Degrader-3

PROTAC ER Degrader-3 Chemical Structure

CAS NO. 2158322-29-1

PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab).

Availability: In stock

Package Price Qty
5 mg
$468.00
10 mg
$806.00
50 mg
$2,392.00
100 mg
$4,784.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab).
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 8.19 mL 40.97 mL 81.94 mL
0.5 mM 1.64 mL 8.19 mL 16.39 mL
1 mM 0.82 mL 4.1 mL 8.19 mL
5 mM 0.16 mL 0.82 mL 1.64 mL

*The above data is based on the productmolecular weight 1220.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18519
Actions Degrader
M. Wt 1220.41
Formula C71H77N7O12
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 2158322-29-1
SMILES OC1=CC=C(/C(C2=CC=C(OCCN(C)C(COCCOCCNC(C3=CC=C(C(N4[[email protected]@H](C)[[email protected]](NC([[email protected]](C)N(C(OC(C)(C)C)=O)C)=O)C(N(CC5=C(OC)C=CC6=C5C=CC=C6)C7=C4C=C(C#N)C=C7)=O)=O)C=C3)=O)=O)C=C2)=C(CC)/C8=CC=CC=C8)C=C1

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