Prucalopride

Catalog No.: A11771

5-HT Receptor agonist

Prucalopride

Prucalopride Chemical Structure

CAS NO. 179474-81-8

Prucalopride is a selective, high affinity 5-HT4 receptor agonist which targets the impaired motility associated with chronic constipation, thus normalising bowel movements.

Availability: In stock

Package Price Qty
5 mg
$40.00
10 mg
$50.00
25 mg
$90.00
50 mg
$140.00
10mM * 1mL in DMSO
$50.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Pierre Meschin, .et al. p11 modulates calcium handling through 5-HT4R pathway in rat ventricular cardiomyocytes., Cell Calcium, 2015, Dec;58(6):549-57 PMID: 26427584

Biological Activity

Prucalopride is a selective, high affinity 5-HT4 receptor agonist which targets the impaired motility associated with chronic constipation, thus normalising bowel movements.
Targets
Target Value
5-HT4Aki: 2.5nM
5-HT4Bki: 8nM
5-HT3ki: 3.822μM
5-HT1Aki: >10μM
5-HT1Bki: >10μM
5-HT1Dki: >10μM
5-HT1Eki: >10μM
5-HT1Fki: >10μM
5-HT2Aki: >10μM
5-HT2Bki: >10μM
5-HT2Cki: >10μM
5-HT5Aki: >10μM
5-HT6ki: >10μM
5-HT7ki: >10μM
In vitro DMSO 52 mg/mL (141.35 mM)
Water Insoluble
Ethanol 33 mg/mL (89.7 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.18 mL 135.91 mL 271.81 mL
0.5 mM 5.44 mL 27.18 mL 54.36 mL
1 mM 2.72 mL 13.59 mL 27.18 mL
5 mM 0.54 mL 2.72 mL 5.44 mL

*The above data is based on the productmolecular weight 367.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11771
Actions Agonist
CAS No. 179474-81-8
Formula C18H26ClN3O3
M. Wt 367.9
Solubility DMSO
Purity >98%
Synonyms Resolor
SMILES COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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