PSB 0777 ammonium is a selective agonist of the adenosine A2A receptor, demonstrating a Ki of 44.4 nM for the rat A2A receptor and 360 nM for the human A2A receptor. It shows significantly reduced affinity for the A1 receptor, with Ki values exceeding 10,000 nM for rats and 541 nM for humans. While PSB 0777 ammonium exhibits limited brain penetration and is not orally absorbable, it holds potential for research applications in inflammatory bowel disease (IBS).
PSB 0777 ammonium is a selective agonist of the adenosine A2A receptor, demonstrating a Ki of 44.4 nM for the rat A2A receptor and 360 nM for the human A2A receptor. It shows significantly reduced affinity for the A1 receptor, with Ki values exceeding 10,000 nM for rats and 541 nM for humans. While PSB 0777 ammonium exhibits limited brain penetration and is not orally absorbable, it holds potential for research applications in inflammatory bowel disease (IBS).
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