PSB-1737 is a selective agonist of the GPR17 receptor, exhibiting an EC50 of 270 nM for human GPR17, with significantly reduced activity on murine GPR17 (EC50 > 10 μM). This compound does not exhibit significant inhibition at the glycine binding site of NMDA receptors, nor does it show notable activity on P2Y receptor subtypes. PSB-1737 is valuable for research in the context of demyelinating diseases, such as multiple sclerosis, and inflammatory-related anemia.
PSB-1737 is a selective agonist of the GPR17 receptor, exhibiting an EC50 of 270 nM for human GPR17, with significantly reduced activity on murine GPR17 (EC50 > 10 μM). This compound does not exhibit significant inhibition at the glycine binding site of NMDA receptors, nor does it show notable activity on P2Y receptor subtypes. PSB-1737 is valuable for research in the context of demyelinating diseases, such as multiple sclerosis, and inflammatory-related anemia.
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