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- Miyayama Y, .et al. Comparative study on the replication of HCV1b genome between wild type and cell culture adaptive mutant in regard to sensitivities against anti-HCV drugs, Microbiol Immunol, 2019, Dec 19 PMID: 31854467
Biological Activity
PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM).
Targets
| NS5B polymerase | ||||
| In vitro | DMSO | Warmed: 86 mg/mL (162.43 mM) | |
| Water | Warmed: 9 mg/mL (16.99 mM) | ||
| Ethanol | 86 mg/mL (162.43 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.89 mL | 94.44 mL | 188.88 mL |
| 0.5 mM | 3.78 mL | 18.89 mL | 37.78 mL |
| 1 mM | 1.89 mL | 9.44 mL | 18.89 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.78 mL |
*The above data is based on the productmolecular weight 529.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11529 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1190307-88-0 |
| Formula | C22H29FN3O9P |
| M. Wt | 529.45 |
| Purity | >98% |
| Synonyms | Sofosbuvir, PSI7977, GI-7977 |
| SMILES | C[[email protected]@H](C(=O)OC(C)C)N[[email protected]](=O)(OC[[email protected]@H]1[[email protected]]([[email protected]@]([[email protected]@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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