PSI-7977

Catalog No.: A11529

HCV Nucleotide Inhibitor

PSI-7977

PSI-7977 Chemical Structure

CAS NO. 1190307-88-0

PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM).

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5 mg

Regular Price: $45.00

Special Price $36.00

10 mg

Regular Price: $65.00

Special Price $52.00

25 mg

Regular Price: $120.00

Special Price $96.00

10mM * 1mL in DMSO

Regular Price: $80.00

Special Price $64.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Miyayama Y, .et al. Comparative study on the replication of HCV1b genome between wild type and cell culture adaptive mutant in regard to sensitivities against anti-HCV drugs, Microbiol Immunol, 2019, Dec 19 PMID: 31854467

Biological Activity

PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM).
Targets
NS5B polymerase
In vitro DMSO Warmed: 86 mg/mL (162.43 mM)
Water Warmed: 9 mg/mL (16.99 mM)
Ethanol 86 mg/mL (162.43 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.89 mL 94.44 mL 188.88 mL
0.5 mM 3.78 mL 18.89 mL 37.78 mL
1 mM 1.89 mL 9.44 mL 18.89 mL
5 mM 0.38 mL 1.89 mL 3.78 mL

*The above data is based on the productmolecular weight 529.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11529
Actions Inhibitor
CAS No. 1190307-88-0
Formula C22H29FN3O9P
M. Wt 529.45
Purity >98%
Synonyms Sofosbuvir, PSI7977, GI-7977
SMILES C[[email protected]@H](C(=O)OC(C)C)N[[email protected]](=O)(OC[[email protected]@H]1[[email protected]]([[email protected]@]([[email protected]@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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