PSI-7977

Catalog No.: A11529

HCV Nucleotide Inhibitor

PSI-7977

PSI-7977 Chemical Structure

CAS NO. 1190307-88-0

PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM).

Availability: In stock

Package Price Qty
5 mg

Regular Price: $60.00

Special Price $48.00

10 mg

Regular Price: $90.00

Special Price $72.00

25 mg

Regular Price: $120.00

Special Price $96.00

10mM * 1mL in DMSO
$80.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM).
Targets
NS5B polymerase
In vitro DMSO 100 mg/mL heating (188.87 mM)
Water 11 mg/mL heating (20.77 mM)
Ethanol 100 mg/mL (188.87 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.89 mL 94.44 mL 188.88 mL
0.5 mM 3.78 mL 18.89 mL 37.78 mL
1 mM 1.89 mL 9.44 mL 18.89 mL
5 mM 0.38 mL 1.89 mL 3.78 mL

*The above data is based on the productmolecular weight 529.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A11529
Actions Inhibitor
M. Wt 529.45
Formula C22H29FN3O9P
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1190307-88-0
Synonyms Sofosbuvir, PSI7977, GI-7977
SMILES C[[email protected]@H](C(=O)OC(C)C)N[[email protected]](=O)(OC[[email protected]@H]1[[email protected]]([[email protected]@]([[email protected]@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3

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