Sofosbuvir (PSI-7977)

Catalog No.: A11529
HCV Nucleotide Inhibitor
PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM).
Grouped product items
Product Name Price Stock Qty
Sofosbuvir (PSI-7977) 5mg
Special Price $36.00 Regular Price $45.00
In stock
Sofosbuvir (PSI-7977) 10mg
Special Price $52.00 Regular Price $65.00
In stock
Sofosbuvir (PSI-7977) 25mg
Special Price $96.00 Regular Price $120.00
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Sofosbuvir (PSI-7977) 10mM * 1mL in DMSO
Special Price $64.00 Regular Price $80.00
In stock
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Adooq Products cited in reputable paper
Adooq's Sofosbuvir (PSI-7977) has been cited by 1 publications
  • Miyayama Y, .et al. , Microbiol Immunol, 2019, Dec 19 PMID: 31854467
  • Biological Activity
    Discription PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM).
    Targets
    Target Value
    Product Information
    Catalog Num A11529
    Formula C22H29FN3O9P
    Molecular Weight 529.45
    CAS Number 1190307-88-0
    SMILES C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3
    Synonyms GI-7977
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro DMSO Warmed: 86 mg/mL (162.43 mM)
    Water Warmed: 9 mg/mL (16.99 mM)
    Ethanol 86 mg/mL (162.43 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 18.89 mL 94.44 mL 188.88 mL
    0.5 mM 3.78 mL 18.89 mL 37.78 mL
    1 mM 1.89 mL 9.44 mL 18.89 mL
    5 mM 0.38 mL 1.89 mL 3.78 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    This equation is commonly abbreviated as: C1V1 = C2V2

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