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|Storage||at -20°C 3 years Powder|
|Synonyms||Sofosbuvir, PSI7977, GI-7977|
|SMILES||C[[email protected]@H](C(=O)OC(C)C)N[[email protected]](=O)(OC[[email protected]@H]1[[email protected]]([[email protected]@]([[email protected]@H](O1)N2C=CC(=O)NC2=O)(C)F)O)OC3=CC=CC=C3|
|Chemical Name||N-[[P(S),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester|
|PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM).|
|Solubility (25°C)*||In vitro||DMSO||100 mg/mL heating (188.87 mM)|
|Water||11 mg/mL heating (20.77 mM)|
|Ethanol||100 mg/mL (188.87 mM)|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||18.89 mL||94.44 mL||188.88mL|
|0.5 mM||3.78 mL||18.89 mL||37.78 mL|
|1 mM||1.89 mL||9.44 mL||18.89 mL|
|5 mM||0.38 mL||1.89 mL||3.78 mL|
*The above data is based on the productmolecular weight 529.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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