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Biological Activity
PTC-209 is a novel potent and selective BMI-1 inhibitor, targeting the BMI-1 self-renewal machinery with an IC50 of ~0.5 μM.
Targets
| BMI-1 (HEK293T cells) | ||||
| 0.5 μM |
| In vitro | DMSO | 92 mg/mL (185.78 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.19 mL | 100.97 mL | 201.94 mL |
| 0.5 mM | 4.04 mL | 20.19 mL | 40.39 mL |
| 1 mM | 2.02 mL | 10.1 mL | 20.19 mL |
| 5 mM | 0.4 mL | 2.02 mL | 4.04 mL |
*The above data is based on the productmolecular weight 495.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13826 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 315704-66-6 |
| Formula | C17H13Br2N5OS |
| M. Wt | 495.19 |
| Purity | >98% |
| Synonyms | PTC209, PTC 209 |
| SMILES | CC1=C(N2C=CC=NC2=N1)C3=CSC(=N3)NC4=C(C=C(C=C4Br)OC)Br |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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