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  1. BMI-1 inhibitor

    PTC-209 is a novel potent and selective BMI-1 inhibitor, targeting the BMI-1 self-renewal machinery with an IC50 of ~0.5 μM.
  2. BMI-1 inhibitor

    PTC-209 HBr is the hydrobromide salt of PTC-209PTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM in HEK293T cell line, and results in irreversible reduction of cancer-initiating cells (CICs).

  3. Bmi1/Ring1A inhibitor

    PRT 4165 is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). It prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2alpha.
  4. BMI-1 inhibitor

    PTC-028 is an orally bioavailable compound that decreases BMI-1 levels by posttranslational modification
  5. BMI-1 inhibitor

    PTC596 is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor.

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