PX20350 is an FXR (Farnesoid X receptor) agonist, exhibiting EC50 values of 83 nM and 10 nM for mouse and human FXR, respectively. This compound significantly induces the expression of NDRG2 mRNA and demonstrates potent anti-tumor activity by inhibiting the growth and metastasis of liver tumor cells, specifically SK-GI-18. Additionally, PX20350 has been shown to possess anti-tumorigenic effects in orthotopic xenograft mouse models, making it valuable for investigating liver cancer biology and therapeutic strategies.
PX20350 is an FXR (Farnesoid X receptor) agonist, exhibiting EC50 values of 83 nM and 10 nM for mouse and human FXR, respectively. This compound significantly induces the expression of NDRG2 mRNA and demonstrates potent anti-tumor activity by inhibiting the growth and metastasis of liver tumor cells, specifically SK-GI-18. Additionally, PX20350 has been shown to possess anti-tumorigenic effects in orthotopic xenograft mouse models, making it valuable for investigating liver cancer biology and therapeutic strategies.
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