QNZ (EVP4593)

Catalog No.: A12748

NF-κB inhibitor

QNZ (EVP4593)

QNZ (EVP4593) Chemical Structure

CAS NO. 545380-34-5

QNZ inhibits the activation of the transcription factor NF-κB and has been used to investigate NF-κB signaling.

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Biological Activity

QNZ inhibits the activation of the transcription factor NF-κB and has been used to investigate NF-κB signaling.
TNF-α (Jurkat T cells) NF-κB (Jurkat T cells)
7 nM11 nM
In vitro (25°C) DMSO Warmed: 5 mg/mL (14.02 mM)
Water Insoluble
Ethanol Insoluble
In vivo 0.5% hydroxyethyl cellulose 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 28.06 mL 140.29 mL 280.58 mL
0.5 mM 5.61 mL 28.06 mL 56.12 mL
1 mM 2.81 mL 14.03 mL 28.06 mL
5 mM 0.56 mL 2.81 mL 5.61 mL

*The above data is based on the productmolecular weight 356.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12748
Actions Inhibitor
CAS No. 545380-34-5
Formula C22H20N4O
M. Wt 356.4
Solubility DMSO
Purity >98%
Synonyms CAY10470, CAY 10470, CAY-10470

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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