Quininib is a cysteinyl leukotriene 1 and 2 receptor antagonist, exhibiting IC50 values of 1.2 μM for CysLT1R and 52 μM for CysLT2R. This compound effectively inhibits developmental angiogenesis in the zebrafish eye model, making it a valuable tool for studying ocular neovascular pathologies. Quininib may serve as a complementary agent to existing anti-VEGF biological therapies in research applications focused on angiogenesis and related conditions.
Quininib is a cysteinyl leukotriene 1 and 2 receptor antagonist, exhibiting IC50 values of 1.2 μM for CysLT1R and 52 μM for CysLT2R. This compound effectively inhibits developmental angiogenesis in the zebrafish eye model, making it a valuable tool for studying ocular neovascular pathologies. Quininib may serve as a complementary agent to existing anti-VEGF biological therapies in research applications focused on angiogenesis and related conditions.
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