(R)-GNE-140

Catalog No.: A21863

LDHA inhibitor

(R)-GNE-140

(R)-GNE-140 Chemical Structure

CAS NO. 2003234-63-5

(R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor, with IC50s of 3 nM and 5 nM for LDHA and LDHB, respectively; (R)-GNE-140 is 18-fold more potent than S enantiomer.

Availability: In stock

Package Price Qty
1 mg
$108.00
5 mg
$324.00
10 mg
$552.00
50 mg
$1,656.00
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Biological Activity

(R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor, with IC50s of 3 nM and 5 nM for LDHA and LDHB, respectively; (R)-GNE-140 is 18-fold more potent than S enantiomer.
In vitro DMSO 88 mg/mL (176.33 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.04 mL 100.19 mL 200.38 mL
0.5 mM 4.01 mL 20.04 mL 40.08 mL
1 mM 2 mL 10.02 mL 20.04 mL
5 mM 0.4 mL 2 mL 4.01 mL

*The above data is based on the productmolecular weight 499.04. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21863
Actions Inhibitor
CAS No. 2003234-63-5
Formula C25H23ClN2O3S2
M. Wt 499.04
Solubility DMSO
Purity >98%
Synonyms GNE140, GNE 140
SMILES O=C1N[[email protected]@](C2=CSC=C2)(C3=CC=C(N4CCOCC4)C=C3)CC(O)=C1SC5=CC=CC=C5Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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