Lactate dehydrogenase A (LDHA)

GNE-140 racemate is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. (R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor.

AZ33 is a LDHA Inhibitor.

Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).

LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively.

GSK2837808A is a potent and selective lactate dehydrogenase A (LDHA) inhibitor with IC50s of 1.9 and 14 nM for LDHA and LDHB, respectively.

FX-11 (LDHA Inhibitor FX11) is a potent lactate dehydrogenase A (LDHA) inhibitor with an IC50 of 23.3 μM for HeLa cell??a Ki value of 8 μM.

(R)-GNE-140 is a potent lactate dehydrogenase A (LDHA) inhibitor, with IC50s of 3 nM and 5 nM for LDHA and LDHB, respectively; (R)-GNE-140 is 18-fold more potent than S enantiomer.

(S)-GNE-140 is the less active enantiomer of GNE-140 which can inhibit Lactate dehydrogenase A (LDHA).

GNE-140 racemic is a novel potent lactate dehydrogenase (LDHA) inhibitor.

Sodium oxamate (SO, Aminooxoacetic acid, Oxamic acid) is an inhibitor of lactate dehydrogenase (LDH) that specificly inhibits LDH?A.

Galloflavin potassium is a selective inhibitor of lactate dehydrogenase, primarily targeting the conversion of pyruvate to lactate. This compound effectively disrupts aerobic glycolysis in PLC/PRF/5 cells, promoting apoptotic cell death. Galloflavin potassium is valuable for research applications related to cancer biology, particularly in studies focused on metabolic reprogramming and the Warburg effect.

Galloflavin is a potent lactate dehydrogenase (LDH) inhibitor, specifically targeting both LDH-A and LDH-B with calculated inhibition constants of 5.46 μM and 15.06 μM, respectively. By inhibiting LDH, Galloflavin disrupts glycolysis and ATP production, thereby hindering the proliferation of cancer cells. This compound is valuable for research applications focused on metabolic regulation and cancer therapeutics.

D-Lactate dehydrogenase, Microorganism (D-LDH) is an oxidoreductase enzyme that catalyzes the conversion of D-lactate to pyruvate, utilizing NAD+ or NADP+ as an electron acceptor. This enzyme is prevalent in various bacteria and fungi, making it a valuable tool in biochemical research. Applications include studies on metabolic pathways, fermentation processes, and the investigation of microbial physiology.

3-Acetylpyridine adenine dinucleotide is a potent inhibitor of lactate dehydrogenase (LDH), an enzyme critical for the conversion of pyruvate to lactate in cellular metabolism. As an analog of nicotinamide adenine dinucleotide (NAD), it offers valuable insight into NAD-dependent enzymatic processes. This compound is useful in both biochemical studies and metabolic research, providing a means to explore LDH's role in various pathophysiological conditions.

Glomeratose A is a potent lactate dehydrogenase inhibitor derived from the plant Polygala tenuifolia. This compound demonstrates significant biological activity by modulating lactate production, thereby impacting metabolic processes associated with various diseases. Research applications include investigations into metabolic pathways, cancer biology, and the role of lactate in cellular signaling.

LDHA-IN-5 is a potent inhibitor of lactate dehydrogenase (LDHA), targeting its enzymatic activity to modulate metabolic pathways. This compound exhibits significant potential in research applications related to metabolic disorders, including primary hyperoxaluria. By inhibiting LDHA, LDHA-IN-5 may help to reduce lactate levels and influence cellular metabolism, making it a valuable tool for understanding disease mechanisms and developing therapeutic strategies.

4-(Dimethylamino)phenol acts as a lactate dehydrogenase (LDH) activator, enhancing extracellular LDH levels without significantly impacting gluconeogenesis. This compound serves as a potent cyanide antidote, facilitating metabolic pathways under certain conditions. Its toxicity arises from the reaction with glutathione, resulting in the formation of covalent complexes that impair cellular function. This reagent is valuable for investigations into metabolic regulation and cellular responses to oxidative stress.