(R)-Nimodipine is an L-type calcium channel blocker that effectively penetrates the blood-brain barrier, with an IC50 value of 5 nM. By inhibiting calcium channels on the hypothalamic-pituitary-adrenal axis, (R)-Nimodipine reduces corticosterone release, thereby mitigating memory impairment and behavioral abnormalities associated with immobilization stress. This compound is frequently utilized in research focused on aneurysmal subarachnoid hemorrhage, cerebral ischemia, epilepsy, age-related neurodegenerative diseases, and the effects of alcohol intoxication.
(R)-Nimodipine is an L-type calcium channel blocker that effectively penetrates the blood-brain barrier, with an IC50 value of 5 nM. By inhibiting calcium channels on the hypothalamic-pituitary-adrenal axis, (R)-Nimodipine reduces corticosterone release, thereby mitigating memory impairment and behavioral abnormalities associated with immobilization stress. This compound is frequently utilized in research focused on aneurysmal subarachnoid hemorrhage, cerebral ischemia, epilepsy, age-related neurodegenerative diseases, and the effects of alcohol intoxication.
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