(R,S,S)-VH032-PEG5-N3 is an E3 ligase ligand-linker conjugate that combines a VHL ligand, derived from VH032, with a five-unit PEG linker. This compound serves as a versatile click chemistry reagent featuring an azide group, which facilitates copper-catalyzed azido-alkyne cycloaddition (CuAAc) when interacting with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted azide-alkyne cycloaddition (SPAAC) with compounds containing DBCO or BCN groups, making it valuable for targeted protein degradation studies and related applications in chemical biology.
(R,S,S)-VH032-PEG5-N3 is an E3 ligase ligand-linker conjugate that combines a VHL ligand, derived from VH032, with a five-unit PEG linker. This compound serves as a versatile click chemistry reagent featuring an azide group, which facilitates copper-catalyzed azido-alkyne cycloaddition (CuAAc) when interacting with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted azide-alkyne cycloaddition (SPAAC) with compounds containing DBCO or BCN groups, making it valuable for targeted protein degradation studies and related applications in chemical biology.
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