Fig. 1 · Structure
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(R)-Vorbipiprant
EP4 Antagonist
(R)-Vorbipiprant is a selective antagonist of the prostaglandin E2 receptor 4 (EP4), exhibiting a binding affinity (Ki) of 16.6 nM for human EP4. It effectively inhibits PGE2-induced cAMP production, with an IC50 value of 22 nM. This compound demonstrates significant immunomodulatory and anti-angiogenic properties, making it a valuable tool for research in inflammation and arthritis, particularly in models of collagen-induced arthritis in mice.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 2502965-92-4 |
| Applications | EP4 Antagonist |
| Formula | C26H27F3N2O3 |
| Molecular Weight | 472.50 |
| Synonyms | (R)-CR6086 |
| SMILES | O=C(C1=CC=C(C2(CC2)NC([C@@H]3N(CCC4(C3)CC4)CC5=CC=C(C(F)(F)F)C=C5)=O)C=C1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.