(R)-Vorbipiprant is a selective antagonist of the prostaglandin E2 receptor 4 (EP4), exhibiting a binding affinity (Ki) of 16.6 nM for human EP4. It effectively inhibits PGE2-induced cAMP production, with an IC50 value of 22 nM. This compound demonstrates significant immunomodulatory and anti-angiogenic properties, making it a valuable tool for research in inflammation and arthritis, particularly in models of collagen-induced arthritis in mice.
(R)-Vorbipiprant is a selective antagonist of the prostaglandin E2 receptor 4 (EP4), exhibiting a binding affinity (Ki) of 16.6 nM for human EP4. It effectively inhibits PGE2-induced cAMP production, with an IC50 value of 22 nM. This compound demonstrates significant immunomodulatory and anti-angiogenic properties, making it a valuable tool for research in inflammation and arthritis, particularly in models of collagen-induced arthritis in mice.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
