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Biological Activity
R1530 is a pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. R1530 is also a mitosis-angiogenesis inhibitor (MAI) that inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR)-1, -2, -3, platelet-derived growth factor receptor (PDGFR) beta? FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.03 mL | 140.14 mL | 280.28 mL |
| 0.5 mM | 5.61 mL | 28.03 mL | 56.06 mL |
| 1 mM | 2.8 mL | 14.01 mL | 28.03 mL |
| 5 mM | 0.56 mL | 2.8 mL | 5.61 mL |
*The above data is based on the productmolecular weight 356.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13111 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 882531-87-5 |
| Formula | C18H14ClFN4O |
| M. Wt | 356.78 |
| Purity | >98% |
| Synonyms | R-1530, R 1530 |
| SMILES | CC1=C2C(=NC3=CC(=C(C=C3C(=N2)C4=CC=CC=C4Cl)F)OC)NN1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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