(Rac)-BRD0705 is a racemic mixture that functions as a selective inhibitor of GSK-3α, exhibiting an IC50 of 66 nM and a Kd of 4.8 μM. This compound demonstrates a notable selectivity for GSK-3α, being eight times more potent than for GSK-3β, which has an IC50 of 515 nM. (Rac)-BRD0705 is relevant for research applications involving acute myeloid leukemia (AML) and other conditions where GSK-3 inhibition may play a critical role in disease mechanisms.
(Rac)-BRD0705 is a racemic mixture that functions as a selective inhibitor of GSK-3α, exhibiting an IC50 of 66 nM and a Kd of 4.8 μM. This compound demonstrates a notable selectivity for GSK-3α, being eight times more potent than for GSK-3β, which has an IC50 of 515 nM. (Rac)-BRD0705 is relevant for research applications involving acute myeloid leukemia (AML) and other conditions where GSK-3 inhibition may play a critical role in disease mechanisms.
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